Objective To evaluate the navigability， supportability， and safety of the Envoy DA catheter in the treatment of anterior circulation aneurysms with carotid artery tortuosity.Methods A total of 49 patients with anterior circulation aneurysms with carotid artery tortuosity who were treated with DA catheters in Jingxian Hospital from January 2017 to December 2020 were analyzed. The clinical data， time of catheter placement， number of coaxial techniques， location of the catheter tip before and at the end of interventional therapy for aneurysms， catheter-related complications， aneurysm embolization degree， and prognosis were analyzed.Results The DA catheters were successfully navigated to the target position in all patients， and the average time of catheter placement was 9.2±5.6 min. The co-axial technique was used to position the DA catheter in the internal carotid artery （ICA） in 10 （20.4%） patients. The location of the DA catheter before treatment involved the cavernous segment of the ICA in 8 patients， the horizontal petrous segment in 15 patients， and the vertical petrous segment in 26 patients. The final angiogram at the end of treatment showed that the catheter tip moved downward in 9 （18.4%） patients， of whom 2 （4.1%） patients underwent replacement of the catheter with the coaxial double catheter system of long sheath + DA catheter because the catheter moved downward to the carotid segment of the ICA. Vasospasm occurred in 3 （6.1%） patients after the DA catheters were in place， and the vasospasm was relieved by pumping nimotop in the artery. There were no catheter-related complications in other patients. After 3 months of follow-up， the modified Rankin scale score was 0 in 33 patients， 1 in 10 patients， and 2 in 6 patients.Conclusions Envoy DA catheter has good navigability and can provide sufficient support during the endovascular embolization of anterior circulation aneurysms with tortuous carotid artery. ［Journal of International Neurology and Neurosurgery, 2022, 49(6): 50-53］