Objective To investigate the influence of flow diverter stents （FDSs） on the covered collateral arteries in the treatment of intracranial aneurysms distal to the circle of Willis.Methods PubMed， EMBASE， Web of Science， and Cochrane Central Database were searched for the articles published up to July 2022 to collect the original studies on the application of FDSs in the treatment of intracranial aneurysms distal to the circle of Willis and the evaluation of the patency rate of collateral vessels covered by FDSs， the incidence rate of complications associated with collateral vessel occlusion， and the cure rate of intracranial aneurysms. Stata 14.0 was used to estimate the pooled rate and 95% confidence interval under the random effects model.Results A total of 7 studies were included in the analysis. The results showed that during follow-up after the treatment of intracranial aneurysms distal to the circle of Willis with FDSs， 34% （95% confidence interval ［CI］： 22%-46%） of the collateral vessels remained unobstructed； 10% （95% CI： 5%-16%） of the patients developed the complications associated with collateral vessel occlusion after surgery； intracranial aneurysms were completely cured in 82% （95% CI： 69%-95%） of the patients， with a cure rate of 88% （95% CI： 75%-100%） in the medium- and long-term follow-up.Conclusions FDSs are highly effective in the treatment of aneurysms distal to the circle of Willis， but collateral vessels should not be covered during surgery to avoid related complications. ［Journal of International Neurology and Neurosurgery, 2022, 49(6): 35-39］