Spinal cord injury （SCI） is one of the most destructive traumatic diseases in humans and is a difficult issue for treatment around the world. It is difficult for neurons to regenerate after injury， which leads to the high disability rate and mortality rate of this disease and brings huge economic burden to the family and the society. The classical Wnt/ β-catenin signaling pathway is an important signal transduction system during the process of SCI. Current studies have confirmed that a variety of exogenous stimuli， such as silent information regulator 2 homolog 1， the laminin-like protein Netrin， microRNA， and heat shock protein， can activate this pathway and regulate the expression of downstream target genes， thereby reducing the autophagy and apoptosis of spinal cord neurons after SCI， inhibiting inflammation， promoting nerve cell proliferation and axon regeneration， reducing the formation of scars， and finally promoting the repair of SCI. This article summarizes the molecular mechanism of the Wnt/ β-catenin signaling pathway in SCI protection in the past three years， in order to provide ideas for discovering new therapeutic targets for SCI.