Cardiovascular disease is one of the most common comorbidities of acromegaly and can increase the risk of death. A series of diseases are associated with acromegaly， such as hypertension， cardiomyopathy， coronary artery disease， arrhythmia， and valvular heart disease. Selection of appropriate surgical treatment， drug therapy， and radiotherapy may help to achieve rapid biochemical remission and improve cardiac function. This article reviews the research advances in the epidemiology and pathogenesis of common cardiovascular comorbidities in patients with acromegaly.