后交通动脉瘤所致动眼神经麻痹患者完全恢复的影响因素
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作者单位:

华中科技大学同济医学院附属同济医院神经外科,湖北 武汉 430000

作者简介:

陈如东(1979—),男,主治医师,主要从事脑脊髓血管病的研究。电话:18502707229,Email:rudongchen@gmail.com。

通信作者:

于加省(1972—),男,主任医师,医学博士,主要从事脑脊髓血管疾病方向的研究。Email:yujiasheng2000@tjh.tjmu.edu.cn。

基金项目:


Influencing factors for complete recovery in patients with oculomotor nerve palsy caused by posterior communicating artery aneurysms
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Affiliation:

Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China

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    摘要:

    目的 分析伴有动眼神经麻痹的中青年后交通动脉瘤患者神经功能完全恢复的影响因素。方法 选取了华中科技大学附属同济医学院附属同济医院2014年1月—2020年1月收治的伴有动眼神经麻痹的后交通动脉瘤患者,年龄18~60岁,根据动眼神经麻痹的恢复情况,将患者分为完全恢复组(63例)和非完全恢复组(26例)。比较两组的临床资料,并分析相关影响因素。结果 动眼神经麻痹类型(OR: 0.144,95% CI:0.030~0.688,P=0.015)、治疗方式(OR: 7.622,95% CI:1.823~31.870,P =0.005)和治疗前动眼神经麻痹持续时间(OR: 0.848,95% CI:0.783~0.919,P =0.000)是神经功能完全恢复的影响因素。结论 在中青年患者中,开颅夹闭比介入栓塞更有利于动眼神经麻痹的完全恢复。术前动眼神经麻痹的类型也与神经功能的完全恢复相关,而完全恢复的最佳预测因素是治疗前症状的持续时间。

    Abstract:

    Objective To investigate the influencing factors for the complete recovery of neurological function in young and middle-aged patients with oculomotor nerve palsy caused by posterior communicating artery aneurysms.Methods The patients (aged 18-60 years) with oculomotor nerve palsy caused by posterior communicating artery aneurysms who were admitted to Tongji Hospital, Tongji Medical College Affiliated to Huazhong University of Science and Technology, from January 2014 to January 2020 were enrolled, and according to the recovery of oculomotor nerve palsy, they were divided into complete recovery group with 63 patients and incomplete recovery group with 26 patients. Related clinical data were compared between the two groups, and related influencing factors were analyzed.Results The logistic regression analysis showed that type of oculomotor nerve palsy (odds ratio [OR] = 0.144, 95% confidence interval [CI]: 0.030-0.688, P = 0.015), treatment modality (OR = 7.622, 95% CI: 1.823-31.870, P = 0.005), and duration of oculomotor nerve palsy before treatment (OR = 0.848, 95% CI: 0.783-0.919, P = 0.000) were influencing factors for the the complete recovery of neurological function.Conclusions In young and middle-aged patients, the treatment modality of craniotomy and clipping has a better clinical effect than interventional embolization in helping with the complete recovery of oculomotor nerve palsy. The severity of oculomotor nerve palsy before surgery is also associated with the complete recovery of neurological function, and the duration of oculomotor nerve palsy before treatment is the best predictive factor for complete recovery.

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陈如东,侯宇阳,厉华,杨洪宽,于加省456.后交通动脉瘤所致动眼神经麻痹患者完全恢复的影响因素[J].国际神经病学神经外科学杂志,2022,49(5):13-17111CHEN Ru-Dong, HOU Yu-Yang, LI Hua, YANG Hong-Kuan, YU Jia-Sheng222. Influencing factors for complete recovery in patients with oculomotor nerve palsy caused by posterior communicating artery aneurysms[J]. Journal of International Neurology and Neurosurgery,2022,49(5):13-17

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  • 收稿日期:2021-11-01
  • 最后修改日期:2022-09-19
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  • 在线发布日期: 2022-11-14
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