Objective To investigate the association of the single nucleotide polymorphisms of the phosphatase and tensin homolog deleted on chromosome 10 （PTEN） gene with the susceptibility to meningioma in the Chinese population.Methods A total of 200 patients with meningioma who underwent neurosurgery in Beijing Tiantan Hospital from October 2017 to January 2018 were enrolled as subjects. The SNaPshot genotyping technique was to detect PTEN gene polymorphisms at rs2735343， rs701848， and rs1234214 loci， and the association of PTEN gene polymorphisms with the susceptibility to meningioma was analyzed.Results There were no significant differences in the genotype and allele frequencies of the rs2735343， rs701848， and rs1234214 loci of the PTEN gene between the meningioma group and the control group （P >0.05）. Haplotype analysis showed that there was a significant difference in the frequency of haplotype CTC between the meningioma group and the control group （P <0.05）， and carriers of haplotype CTC had an increased risk of meningioma （odds ratio = 1.366， 95% confidence interval： 1.034-1.805， P = 0.028）.Conclusions PTEN gene polymorphisms may not be associated with the susceptibility to meningioma； however， the haplotype CTC comprised of rs2735343， rs701848， and rs1234214 may be a risk factor for meningioma in the Chinese population.