Silent information regulator 3 （SIRT3） is a NAD⁺-dependent class III histone deacetylase. SIRT3 plays important roles in improving cognition， regulating aging， and prolonging life by deacetylating histone and non-histone proteins. Recent studies have demonstrated that over expressed SIRT3 can reduce oxidative stress and the abnormal aggregation of α-synuclein to exert protective effects in the rotenone-induced Parkinson’s disease model. In this paper， we review recent research progress on the regulatory role of SIRT3 in mitochondrial autophagy and oxidative stress， and hope to provide a reference for basic research on the treatment of Parkinson’s disease.