Autophagy is a highly conserved catabolic process of cells induced by various stress conditions. It can prevent cell damage， promote cell survival in the absence of energy or nutrition， and provide protection against various cytotoxic stimuli. Defects in autophagy can cause many human diseases， and have been shown to have clear etiological links to neurodegenerative diseases， inflammatory diseases， and cancer. Autophagy has been demonstrated to regulate the development and progression of medulloblastoma through multiple signaling pathways. Therefore， regulating autophagy pathways may be a new approach to treating medulloblastoma. This article reviews recent research progress on medulloblastoma and autophagy-related regulatory mechanisms.