Brain tumor is a group of diseases with heterogeneity in pathological type， biological behavior， treatment， and prognosis， among which glioma and metastasis are particularly prominent. Pathological diagnosis is crucial in clinical practice. As one of the most widely used methods， biopsy has the advantages of less trauma and quick recovery. With the existing navigation equipment， an accurate biopsy of specific parts can be achieved. However， ultra-high-precision stereotactic biopsy sometimes fails to obtain satisfactory pathological information due to human factors， tumor heterogeneity， sample insufficiency， and other influences. At present， there are many imaging techniques related to tumor metabolism， and there have been a lot of studies using metabolism-related imaging to select biopsy targets. A literature review of related studies is now conducted.