Objective To investigate the influence of diabetes/hyperglycemia on the prognosis of intracranial hemorrhage by extracting related data from animal experiments.Methods CNKI， Wanfang Data， PubMed， Web of Science， the Cochrane Library， and Embase were systematically searched for related animal experiments of diabetes/hyperglycemia and intracranial hemorrhage published up to November 1， 2021. Screening was performed in strict accordance with inclusion and exclusion criteria， and a random effects model or a fixed effects model was used to estimate pooled rate and 95% confidence interval （CI）. The SYRCLE tool for assessing risk of bias was used for quality assessment. Review Manager 5.3 software was used to perform a meta-analysis of the experiments included to investigate the influence of diabetes/hyperglycemia on the prognosis of intracranial hemorrhage.Results A total of 7 animal experiments were included， and the meta-analysis showed that in the animal model of intracerebral hemorrhage， the diabetes/hyperglycemia group had a significantly larger hematoma volume than the control group ［standardized mean difference （SMD）=1.2， 95%CI： 0.13-2.27， P<0.05］. Further subgroup analysis showed that there was no significant difference in hematoma volume between the two groups within the first 3 days （SMD=0.68， 95%CI： -0.38 to 1.74， P>0.05）， while the diabetes/hyperglycemia group had a significantly larger hematoma volume than the control group on day 7 （SMD=3.26， 95%CI： 0.21-6.31， P>0.05）. The diabetes/hyperglycemia group had a significantly higher degree of perihematomal edema （PHE） than the control group ［mean difference （MD）=1.57， 95%CI： 0.71-2.44， P<0.05］. The diabetes/hyperglycemia group had a significantly higher neurological function score than the control group （SMD=1.06， 95%CI： 0.50-1.62， P<0.05）.Conclusions In animal experiments， diabetes/hyperglycemia can increase hematoma volume and the degree of PHE， thereby affecting the prognosis of intracerebral hemorrhage.