帕金森病患者血清中Toll样受体4及下游炎症因子的高表达与临床分期及分型的关系研究
作者:
作者单位:

1.新乡医学院第一附属医院,河南 卫辉 453100;2.新乡医学院第三附属医院,河南 新乡 453000;3.新乡医学院,河南 新乡 453000

作者简介:

郭清华(1994—),女,神经内科住院医师,硕士在读,主要从事脑血管病及神经变性疾病的研究。

通信作者:

邢红霞(1972—),女,教授,主任医师,硕士生导师,主要从事脑血管病及神经变性疾病的研究。Email:xhxwh02@163.com。

基金项目:

河南省科技攻关项目基金(182102310156);河南省医学科技攻关计划省部共建项目基金(SBGJ202002095);河南省医学科技攻关计划联合共建项目基金(LHGJ20210548)。


Association of the high expression of serum Toll-like receptor 4 and downstream inflammatory factors with clinical staging and typing in patients with Parkinson’s disease
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Affiliation:

1.The First Affiliated Hospital of Xinxiang Medical university, Weihui, Henan 453100, China;2.The Third Affiliated Hospital of Xinxiang Medical university, Xinxiang, Henan 453000, China;3.Xinxiang Medical university, Xinxiang, Henan 453000, China

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    摘要:

    目的 检测Toll样受体4(TLR4)及白介素6(IL-6)、白介素1β(IL-1β)和肿瘤坏死因子α(TNF-α)在帕金森病(PD)患者血清中的表达,探讨TLR4及下游炎症因子与PD发生发展的关系。方法 选取2019年 9月至 2020 年9月于新乡医学院第一附属医院神经内科门诊和病房就诊的原发性PD患者60例(PD组),以及同期在该院体检健康者60例(对照组)。采用酶联免疫吸附试验(ELISA)检测其血清TLR4蛋白及IL-6、IL-1β 和TNF-α水平,并分析其与PD患者Hoehn-Yahr分期和临床分型的关系。结果 PD组外周血血清TLR4水平高于对照组,差异有统计学意义(P<0.05);下游炎症因子IL-6、IL-1β和TNF-α水平高于对照组,差异有统计学意义(均P<0.05)。PD分期越高,TLR4、IL-6、IL-1β 和TNF-α的表达越高。震颤为主型、强直少动型和混合型PD患者TLR4、IL-6、IL-1β和TNF-α的表达差异无统计学意义(P>0.05)。结论 TLR4及其下游炎症因子的高表达与PD的发生发展和分期密切相关,对PD发病机制的研究具有重要意义。 [国际神经病学神经外科学杂志, 2022, 49(3): 41-45.]

    Abstract:

    Objective To investigate the association of Toll-like receptor 4 (TLR4) and downstream inflammatory factors with the development and progression of Parkinson’s disease (PD) by measuring the expression of TLR4, interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in the serum of patients with PD.Methods A total of 60 patients with primary PD who were treated at the outpatient service and ward of Department of Neurology in The First Affiliated Hospital of Xinxiang Medical College from September 2019 to September 2020 were enrolled as PD group, and 60 individuals who underwent physical examination in this hospital during the same period of time were enrolled as control group. ELISA was used to measure the serum levels of TLR4, IL-6, IL-1β, and TNF-α, and their association with the Hoehn-Yahr staging and clinical typing of PD patients was analyzed.Results Compared with the control group, the PD group had significantly higher serum levels of TLR4 and the downstream inflammatory factors IL-6, IL-1β, and TNF-α in peripheral blood (all P<0.05). The patients with higher PD stages tended to have higher expression levels of TLR4, IL-6, IL-1β, and TNF-α. There were no significant differences in the expression of TLR4, IL-6, IL-1β, and TNF-α between the patients with tremor-dominant, akinetic-rigid, and mixed subtypes of PD (P>0.05).Conclusions The high expression of TLR4 and its downstream inflammatory factors is closely associated with the development, progression, and staging of PD, which is of great significance for the research on the pathogenesis of PD. [Journal of International Neurology and Neurosurgery, 2022, 49(3): 41-45.]

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郭清华,郭彦杰,宋净洋,左书茜,刘梦豪,邢红霞,李超堃456.帕金森病患者血清中Toll样受体4及下游炎症因子的高表达与临床分期及分型的关系研究[J].国际神经病学神经外科学杂志,2022,49(3):41-45111GUO Qing-Hua, GUO Yan-Jie, SONG Jing-Yang, ZUO Shu-Qian, LIU Meng-Hao, XING Hong-Xia, Li Chao-Kun222. Association of the high expression of serum Toll-like receptor 4 and downstream inflammatory factors with clinical staging and typing in patients with Parkinson’s disease[J]. Journal of International Neurology and Neurosurgery,2022,49(3):41-45

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  • 收稿日期:2021-12-17
  • 最后修改日期:2022-05-07
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  • 在线发布日期: 2022-08-29
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