Objective To explore the effects of bromocriptine on the survival rate， hatching time， and morphological development of zebrafish embryos.Methods Zebrafish embryos were randomly divided into bromocriptine solution groups （10-μmol/L， 20-μmol/L， 50-μmol/L， and 100-μmol/L groups）， blank control group， and 0.5% dimethyl sulfoxide control group. These groups were compared with regard to the survival rate， hatching time， swim bladder inflation， and deformities and anomalies.Results At 48 hours post fertilization （HPF）， the bromocriptine groups showed significantly lower hatching rates than the two control groups （all P <0.05）. At 120 HPF， the 20-μmol/L， 50-μmol/L， and 100-μmol/L bromocriptine groups showed significantly lower swim bladder inflation rates and significantly higher edema rates than the other groups （all P <0.05）， but without significant differences in the rate of deformities between groups （all P >0.05）. At 144 HPF， the survival rate of zebrafish larvae was significantly lower in the 50-μmol/L and 100-μmol/L bromocriptine groups than in the other four groups （all P <0.05）.Conclusion High concentrations of bromocriptine can delay embryos’ hatching， reduce larvae’s survival rate， and cause edema and impaired swim bladder inflation in zebrafish， but have no association with the developmental deformities of zebrafish embryos.