Abnormal regulatory network of ferroptosis, dopamine and neuromelanin played an important role in the pathogenesis of Parkinson’s disease (PD), and the intrinsic mechanism remained to be elucidated. The effects of ferroptosis were correlated with oxidative stress, mitochondrial dysfunction and accumulation of α-synuclein, which might be the common pathways underlying PD pathogenesis. The interaction of ferroptosis and dopamine enhanced the production of lipid oxidation, decreased neuromelanin synthesis and lead to cell death. The research progress of the regulatory network of ferroptosis, dopamine and neuromelanin in PD was summarized.