Objective To investigate the clinical effect of Neuroform EZ stent implantation as an adjuvant therapy for the treatment of symptomatic severe middle cerebral artery stenosis.Methods A retrospective analysis was performed on the clinical data of 85 patients with symptomatic severe middle cerebral artery stenosis who were admitted to the Affiliated Hospital of Chengde Medical College from October 2016 to October 2019. The patients were divided into observation group （n=43） and control group （n=42） according to their treatment regimen. The control group was given medication alone， and the observation group was given medication combined with Neuroform EZ stent implantation. The two groups were compared in terms of treatment outcome and incidence of adverse events 1 year after operation， and cognitive function score ［Mini-Mental State Examination （MMSE）］， neurological deficit score ［National Institutes of Health Stroke Scal e（NIHSS）］， cerebral blood perfusion parameters ［cerebral blood flow （CBF） and cerebral blood volume （CBV）］， and vascular endothelial function parameters ［nitric oxide （NO） and endothelin （ET）］ before operation and 6 months and 1 year after operation.Results The observation group had a significantly high eroverall response rate than the control group at 1 year after operation （95.35% vs 78.57%， P<0.05）. At 6 months and 1 year after operation， the MMSE score， CBF， CBV， and serum NO level in the two groups were significantly increased， and the separameters in the observation group were significantly higher than those in the control group （all P<0.05）； the NIHSS score and serum ET level in the two groups were significantly reduced， and these parameters in the observation group were significantly lower than those in the control group （all P<0.05）. The observation group had a significantly lower incidence rate of adverse events than the control group （13.95% vs 33.33%， P<0.05）.Conclusions Neuroform EZ stent implantation in the adjuvant treatment of symptomatic severe middle cerebral artery stenosis can promote the improvement of cognitive and neurological function， and play a positive role in improving cerebral blood perfusion， vascular endothelial function， and reducing adverse events.