保定市第四中心医院 神经外科，河北 保定 072350
刘凤民（1970—），男，汉，本科，副主任医师，研究方向：神经外科，Tel:13930803169，Email：bzzo4g@163.com。
Department of Neurosurgery， Baoding Fourth Central Hospital， Baoding， Hebei 072350， China
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目的 探究血清神经珠蛋白（NGB）、脑钠肽（BNP）水平与颅脑损伤（TBI）患者伤情严重程度及预后的相关性。方法 以127例TBI患者为研究对象，99例健康志愿者作为对照。利用ELISA法检测血清中的NGB和BNP水平，格拉斯哥预后评分(GOS)判断预后。分析TBI患者治疗前血清中NGB和BNP的含量与TBI程度的关系。结果 末次随访TBI患者预后良好组血清中NGB和BNP的含量低于预后不良组（P<0.05）。TBI患者血清中NGB和BNP的含量与TBI程度成正相关（r=0.705，0.781；P<0.05），与格拉斯哥昏迷评分（GOS）评分呈负相关（r=-0.886，-0.812；P<0.05）。血清中NGB含量与TBI程度有相关性(OR=1.059，95％CI:1.004~1.325，P=0.030)。ROC曲线结果显示，血清中BNP含量与TBI程度有相关性(OR=1.217，95％CI:1.015～1.377，P=0.020)。结论 血清NGB、BNP水平与TBI患者伤情严重程度及预后康复效果呈正相关。
Objective To investigate the correlation of the serum levels of neuroglobin （NGB） and brain natriuretic peptide （BNP） with the severity and prognosis of patients with traumatic brain injury （TBI）.Methods A total of 127 patients with TBI were enrolled as subjects， and 99 healthy volunteers were enrolled as controls. ELISA was used to measure the serum levels of NGB and BNP， and Glasgow Outcome Scale （GOS） was used to evaluate prognosis. and analysis the relationship between the serum levels of NGB and BNP and the severity of TBI before treatment.Results The TBI patients with good prognosis at final follow-up had significantly lower serum levels of NGB and BNP than those with poor prognosis （P <0.05）. In the patients with TBI， the serum levels of NGB and BNP were positively correlated with the severity of TBI （r = 0.705 and 0.781， P <0.05） and were negatively correlated with GOS score （r = -0.886 and -0.812， P <0.05）. The serum level of NGB was associated with the severity of TBI （odds ratio ［OR］ = 1.059， 95% confidence interval ［CI］： 1.004-1.325， P = 0.030）. The receiver operating characteristic curve analysis showed that the serum level of BNP was associated with the severity of TBI （OR = 1.217， 95% CI： 1.015-1.377， P = 0.020）.Conclusions The serum levels of NGB and BNP are positively correlated with the severity and prognosis of patients with TBI.
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刘凤民,左苗英456.血清NGB、BNP水平与颅脑损伤患者伤情严重程度及预后的相关性研究[J].国际神经病学神经外科学杂志,2021,48(5):443-446111LIU Feng-Min, ZUO Miao-Ying222. Correlation of the serum levels of neuroglobin and brain natriuretic peptide with the severity and prognosis of patients with traumatic brain injury[J]. Journal of International Neurology and Neurosurgery,2021,48(5):443-446
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- 收稿日期:2021-04-19
- 最后修改日期:2021-09-30
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- 在线发布日期: 2021-11-15
