Objective To investigate the incidence of lower extremity deep venous thrombosis in patients with cerebral infarction and analyze the associated risk factors.Methods The clinical data of 431 patients with cerebral infarction admitted to the Affiliated Hospital of Southwest Medical University from March 2018 to November 2019 were divided into two groups with （n=52） and without （n=379） lower extremity deep venous thrombosis. The clinical data of the two groups were compared and the associated risk factors were analyzed.Results There were significant differences between the two groups in age （≥60 years）， history of hypertension， history of diabetes， history of hyperlipidemia， history of malignancy， concomitant infection， National Institute of Health Stroke Scale （NIHSS） score ≥16， administration of dehydrating agent ≥4 times/day， bedtime ≥14 days， interventional therapy， and use of clopidogrel （P<0.05）. Multivariate logistic regression analysis showed that concomitant hypertension， administration of dehydrating agent ≥4 times/d， NIHSS score ≥16， and concomitant infection were risk factors for lower extremity deep venous thrombosis in patients with cerebral infarction （P<0.05）.Conclusions The occurrence of lower extremity deep venous thrombosis in patients with cerebral infarction is the result of multiple factors. ［Citation:Journal of International Neurology and Neurosurgery, 2021, 48(3): 280-283］