血清Copeptin、IGF-Ⅱ联合APACHE Ⅱ评分对颅脑外伤患者预后的预测价值
作者:
作者单位:

徐州市中心医院重症医学科,江苏 徐州 221000

作者简介:

李祥全,男,硕士研究生,研究方向为重症医学,Email:amytoj@163.com。

通信作者:

闫肃(1982-),男,副主任医师,硕士研究生,主要从事重症医学的研究,Email:bife5148@163.com。

基金项目:


Value of serum levels of copeptin and insulin-like growth factor-II combined with Acute Physiology and Chronic Health Evaluation II score in predicting the prognosis of patients with traumatic brain injury
Author:
Affiliation:

Department of Critical Care Medicine, Xuzhou Central Hospital, Xuzhou, Jiangsu 221000, China

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    摘要:

    目的 探究血清Copeptin、IGF-Ⅱ联合APACHE Ⅱ评分对颅脑外伤患者预后的预测价值。方法 选取2012年12月1日—2018年12月1日于该院就诊的96例颅脑外伤患者作为实验组,同时选取96例健康者作为对照组。所有患者均进行血清Copeptin、IGF-Ⅱ水平的检测。评估实验组患者预后情况,分析不同预后患者的血清Copeptin、IGF-Ⅱ水平。结果 实验组患者入院后血清Copeptin水平逐渐降低,IGF-Ⅱ水平逐渐升高。轻型组、中型组和重型组之间的Copeptin和IGF-II水平有差异(P<0.05);轻型组患者IGF-Ⅱ水平高于中型组,Copeptin水平低于中型组;中型组患者血IGF-Ⅱ水平高于重型组,Copeptin水平低于重型组。APACHE Ⅱ评分与Copeptin水平呈正相关,与血清IGF-II水平呈负相关。实验组患者出院后6个月后,预后越差,入院时血清Copeptin水平越高,IGF-Ⅱ水平越低。结论 通过血清Copeptin、IGF-Ⅱ水平联合APACHE Ⅱ评分对颅脑外伤患者预后有一定预测价值。

    Abstract:

    Objective To investigate the value of serum copeptin and insulin-like growth factor-II (IGF-II) combined with Acute Physiology and Chronic Health Evaluation II (APACHE II) score in predicting the prognosis of patients with traumatic brain injury.Methods A total of 96 patients with traumatic brain injury who attended our hospital from December 1, 2012 to December 1, 2018 were enrolled as experimental group, and 96 healthy individuals were enrolled as control group. The serum levels of copeptin and IGF-II were measured for all subjects. The prognosis of the patients in the experimental group were evaluated, and the serum levels of copeptin and IGF-II were analyzed for patients with different prognoses.Results After admission, the experimental group had a gradual reduction in the serum level of copeptin and a gradual increase in the serum level of IGF-II. There were significant differences in the serum levels of copeptin and IGF-II between the mild group, the moderate group, and the severe group (P <0.05); compared with the moderate group, the mild group had a higher level of IGF-II and a lower level of copeptin, and compared with the severe group, the moderate group had a higher level of IGF-II and a lower level of copeptin. APACHE II score was positively correlated with copeptin level and negatively correlated with serum IGF-II level. For the patients in the experimental group at 6 months after discharge, the worse the prognosis, the higher the serum level of copeptin and the lower the serum level of IGF-II on admission.Conclusions Serum levels of copeptin and IGF-II combined with APACHE II score have a certain value in predicting the prognosis of patients with traumatic brain injury.

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李祥全,姜莹,丁华锋,闫肃.血清Copeptin、IGF-Ⅱ联合APACHE Ⅱ评分对颅脑外伤患者预后的预测价值[J].国际神经病学神经外科学杂志,2021,48(3):231-234

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  • 收稿日期:2020-09-13
  • 最后修改日期:2021-06-07
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  • 在线发布日期: 2021-08-27
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