集落刺激因子-1受体在部分中枢神经系统疾病中的研究进展
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作者单位:

1.上海交通大学医学院,上海 200025;2.上海交通大学医学院附属瑞金医院神经外科,上海 200025

作者简介:

李昌盛(1995-),男,上海交通大学医学院临床医学在读博士研究生;主要研究方向为神经系统肿瘤。

通信作者:

吴哲褒(1973-),男,主任医师,教授,博导。专业特长: 神经系统肿瘤; 垂体瘤的临床与基础研究。Email: zhebaowu@aliyun.com。

基金项目:

国家自然科学基金(81972339,81671371)


Research Progress of Roles Played by CSF-1R in Central Nervous System DiseasesLI Chang-Sheng1, CHENG Yi-Jun2, WU Zhe-Bao21.School of MedicineShanghai Jiao Tong UniversityShanghai 200025,China;2.Department of Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of MedicineShanghai 200025,China
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    摘要:

    集落刺激因子-1受体又称巨噬细胞集落刺激因子受体(M-CSFR)或CD115,是单核吞噬细胞及其前体的生长调控因子,在中枢神经系统中能够直接参与小胶质细胞的分化及生长。然而,目前其作用机制、临床应用及安全性仍处于研究阶段。该文针对集落刺激因子-1受体在神经系统发育过程中的作用及与之相关神经退行性疾病进行综述,并阐述其在中枢神经系统常见肿瘤免疫微环境中发挥的作用,为后续研究及中枢神经系统疾病的免疫、基因治疗提供参考。国际神经病学神经外科学杂志, 2021, 48(1): 69-73]

    Abstract:

    Colony-stimulating factor 1 receptor (CSF-1R), also known as macrophage colony stimulating factor receptor (M-CSFR) or CD115, is a growth regulator of mononuclear phagocytes and their precursors, which is directly involved in the differentiation and growth of microglia in the central nervous system (CNS). However, its action mechanisms, clinical application, and potential safety are still in the research stage. This article reviews the role of CSF-1R in the development of the CNS and related neurodegenerative diseases, and further explores the role of CSF-1R in the immune microenvironment of common CNS tumors, which seems to be useful for the follow-up research, immunization, and gene therapy.Journal of International Neurology and Neurosurgery, 2021, 48(1): 69-73]

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李昌盛,成宜军,吴哲褒456.集落刺激因子-1受体在部分中枢神经系统疾病中的研究进展[J].国际神经病学神经外科学杂志,2021,48(1):69-73111222. Research Progress of Roles Played by CSF-1R in Central Nervous System DiseasesLI Chang-Sheng1, CHENG Yi-Jun2, WU Zhe-Bao21. School of MedicineShanghai Jiao Tong UniversityShanghai 200025,China;2. Department of Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of MedicineShanghai 200025,China[J]. Journal of International Neurology and Neurosurgery,2021,48(1):69-73

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  • 收稿日期:2020-01-25
  • 最后修改日期:2021-02-02
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  • 在线发布日期: 2021-06-03
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