Neuroscientists traditionally view brain as a kind of "immune immunity" organ, and the immune surveillance of the central nervous system functions against pathogens and tumors insufficiently. However, with the in-depth study of the lymphatic network, neuroscientists seem to find traces of the lymphatic system in the central nervous system. Several recent studies have corroborated the existence of lymphatic vessels in the brain and have given a preliminary description of them. The anatomical structure and function of brain lymphatic vessels show us the overall perspective of intracranial fluid dynamics, and address multiple clinical problems. More importantly, these findings open new avenues up for the treatment of central nervous system-related diseases. By reviewing the history of cerebral lymphatic network researches, this review summarizes the circulation process of brain interstitial fluid and cerebrospinal fluid. Herein, we briefly introduce the role of this lymphatic system in the pathophysiological process and treatment of various central nervous system-related diseases.