Objective To investigate the trend of hemodynamic changes in patients with intracranial aneurysms undergoing interventional surgery during operation and recovery period and the effect of clinical drug intervention.Methods 86 patients with intracranial aneurysms undergoing interventional surgery in our hospital (November 2017-June 2019) were randomly divided into study group (n=43) and control group (n=43).The control group was treated with remifentanil and sevoflurane, while the study group was treated with dexmedetomidine on the basis of the control group.The perioperative hemodynamic indexes, cerebral oxygen metabolism, extubation, eye opening and recovery of spontaneous breathing, and adverse reactions of the two groups were counted before anesthesia induction (T0), after tracheal intubation (T1), 15 minutes after anesthesia (T2), and after operation (T3).Results (1) Hemodynamics: (i) Differences in HR, MAP, SBP and SPO₂ at different time points (P<0.05), (ii) differences in HR, MAP, SBP and SPO₂ between groups (P<0.05) and (iii) differences in trends in HR, MAP, SBP and SPO₂ between study and control groups (P<0.05). (2) Cerebral oxygen metabolism: (i) Differences in CERO₂ and Da-jvO₂ at different time points (P<0.05), (ii) differences in CERO₂ and Da-jvO₂ between groups (P<0.05) and (iii) differences in trends in CERO₂ and Da-jvO₂ between study and control groups (P<0.05). (3) Extubation, eye opening and recovery of spontaneous breathing time: the extubation time of the study group was shorter than that of the control group (P<0.05), and there was no significant difference in the opening time and recovery of spontaneous breathing time between the study group and the control group (P>0.05).(4) Adverse reactions: The incidence of adverse reactions in the study group (13.95%) was lower than that in the control group (32.56%) (P<0.05).Conclusions Abnormal hemodynamic fluctuations in intracranial aneurysm patients during operation and recovery period can be inhibited by dexmedetomidine combined with sevoflurane, which can improve cerebral oxygen metabolism, shorten the extubation time after operation, and the incidence of adverse reactions is low, so it is safe.