Objective To investigate the clinical effect of minimally invasive drilling and drainage combined with enhanced recovery after surgery program in patients with cerebral hemorrhage.Methods Eighty patients with hypertensive cerebral hemorrhage (within 30~50 ml hemorrhagic volume) from April 2019 to June 2020 were collected. The patients were divided into traditional group (minimally invasive drilling and drainage combined with traditional perioperative program, 40 cases) and ERAS group (minimally invasive drilling and drainage combined with enhanced recovery after surgery program, 40 cases) according to random number table method. Differences in recovery and complications were compared between these two groups after surgery.Results The incidence of intracranial infection and lung infection urinary tract infection in ERAS group was significantly lower than those in traditional group, and the differences were statistically significant (P<0.05). Compared to the traditional group, the time of patients staying in hospital was shorter and the hospital costs reduced in ERAS group (P<0.05). The Barthel Index score and European Stroke Scale score in the ERAS group was better than that in the traditional group (P<0.05). The time of patients staying in hospital in ERAS group was significantly shorter than that in traditional group (P<0.05). The Inflammation indexes of CRP and IL-6 on days 3 after surgery were lower in the ERAS group than the traditional group (P<0.05).There was no significant difference in the status of Surgical incision healing between the two groups (P>0.05).Conclusions Minimally invasive drilling and drainage combined with enhanced recovery after surgery program can accelerate recovery and reduce complications in the treatment of patients with cerebral hemorrhage, which is safe and effective for clinical application.