Magnetic fluid hyperthermia (MFH) is a non-invasive, nanotechnology-based local hyperthermia therapy. In MFH, magnetic nanoparticles as a heating mediator are exposed to an external alternating magnetic field and heated to 41~46℃. The high temperature kills tumor cells through a variety of mechanisms. Compared to traditional hyperthermia, MFH has several advantages including high biosafety, deep tissue penetration, targeted delivery, and selective killing, and thus has become an important topic in the field of nanomedicine. In this paper, we provide a brief review of the latest advances of MFH in the treatment of malignant tumors of the central nervous system.