Objective To investigate the efficacy of hyperbaric oxygen combined with atorvastatin in the conservative treatment of chronic subdural hematoma.Methods A retrospective analysis was performed on the clinical data of 116 patients with chronic subdural hematoma who were admitted to No. 987 Hospital of the PLA Joint Logistics Support Force, Baoji High-tech People's Hospital, and The Third People's Hospital of Baoji City and systematically treated with hyperbaric oxygen combined with atorvastatin from March 2015 to March 2018 (group A); and the treatment outcome of group A was compared with that of 122 patients with chronic subdural hematoma who were admitted to these three hospitals and received conventional conservative treatment from February 2012 to February 2015 (group B).Results A total of 104 patients (89.66%) in group A and 66 patients (54.10%) in group B were successfully treated with conservative treatment and achieved improvements in their conditions. The mean cost of treatment was 8523.65±717.85 yuan in group A and 9723.26±1534.85 yuan in group B. The degree of satisfaction was 87.07% (101 patients) in group A and 70.49% (86 patients) in group B. There were significant differences in patients' improvement rate and degree of satisfaction between the two groups (both P<0.05).Conclusions Systematic hyperbaric oxygen combined with atorvastatin treatment can increase the improvement rate of patients with chronic subdural hematoma in the conservative treatment, improve the degree of patients' satisfaction with the treatment, and reduce the mean cost of treatment.