颅内宽颈动脉瘤破裂急性期LVIS支架辅助弹簧圈栓塞治疗
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李钢(1969-),博士研究生,主任医师,主要从事脑血管病方向的研究。Email:lig0550@126.com

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2014年三亚市医疗卫生科技创新项目(2014YW40)。


LVIS stent-assisted coil embolization in treating ruptured wide-necked intracranial aneurysms in the acute stage
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    摘要:

    目的 探讨颅内宽颈动脉瘤破裂出血急性期应用LVIS支架辅助弹簧圈栓塞治疗的策略。方法 回顾2017年1月—2019年12月应用LVIS支架辅助弹簧圈栓塞的17例颅内宽颈动脉瘤破裂(共19个动脉瘤)患者资料。栓塞术前阿司匹林和氯吡格雷各300mg口服或肛门给药,术中常规体内肝素化。采用Raymond分级标准评价栓塞效果。术后口服阿司匹林(100 mg/日,持续6个月),氯吡格雷(75 mg/d,持续3个月)。临床治疗效果评估采用改良Rankin量表(modified Rankin Scale,mRS),0~2级属预后良好。结果 17例患者支架均完全释放,技术成功率100%。栓塞后即刻造影均显示完全填塞。在栓塞治疗中有2例(11.8%)患者发生颅内血管栓塞,经微导管注入替罗非班5~10 mL后血管再通。1例术后因呼吸衰竭而死亡。1例术后因急性心梗死亡。存活患者预后mRS 0分5例,1分3例,2分6例,3分1例。预后良好率88.2%。无支架相关不良事件发生。结论 LVIS支架辅助弹簧圈栓塞急性期破裂宽颈动脉瘤可获得良好的栓塞效果,但围手术期风险及远期疗效有待于进一步大样本随访研究。

    Abstract:

    Objective To explore the strategy of LVIS stent-assisted coil embolization in treating ruptured wide-necked intracranial aneurysms in the acute stage. Methods A retrospective analysis was performed on the clinical data of 17 patients with ruptured wide-necked intracranial aneurysms (a total of 19 aneurysms) who were treated with LVIS stent-assisted coil embolization from January 2017 to December 2019. Before the operation, all patients received oral or rectal administration of aspirin and clopidogrel, each at a dose of 300 mg. During the operation, conventional heparinization was performed. The Raymond classification was used to assess the effectiveness of embolization. After the operation, all patients received oral administration of aspirin (100 mg/d for 6 months) and clopidogrel (75 mg/d for 3 months). The modified Rankin Scale (mRS) was used to evaluate the clinical efficacy, and grade 0~2 represented a good prognosis. Results In this group of patients, 17 stents were completely released, with a success rate of 100%. The angiography immediately after embolization showed that all the aneurysms were completely occluded. Two patients (11.8%) developed intracranial vascular embolism during the embolization therapy. After 5~10 mL of tirofiban injection, the vessels were recanalized. After the operation, one patient died of respiratory failure, and another died of acute myocardial infarction. Among the surviving patients, the prognostic mRS score was as follows:0 in 5 cases, 1 in 3 cases, 2 in 6 cases, and 3 in 1 case, with a good prognosis rate of 88.2%. No stent-related adverse events occurred. Conclusions LVIS stent-assisted coil embolization has a good effect in treating ruptured wide-necked aneurysms in the acute stage, but its risk and long-term efficacy still need large-sample studies and follow-up.

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刘珍, 王辉, 肖仕和, 李钢456.颅内宽颈动脉瘤破裂急性期LVIS支架辅助弹簧圈栓塞治疗[J].国际神经病学神经外科学杂志,2020,47(3):239-243111LIU Zhen, WANG Hui, XIAO Shi-He, LI Gang222. LVIS stent-assisted coil embolization in treating ruptured wide-necked intracranial aneurysms in the acute stage[J]. Journal of International Neurology and Neurosurgery,2020,47(3):239-243

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  • 收稿日期:2020-03-26
  • 最后修改日期:2020-06-18
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  • 在线发布日期: 2020-06-28
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