Objective To analyze the risk factors for poor prognosis of intracranial aneurysm after interventional surgery. Methods A retrospective analysis was performed on the clinical data of 304 patients with intracranial aneurysm who had undergone interventional embolization in our hospital from January 2017 to January 2019. The data of the patients were compiled according to patient's sex, age, past medical history, aneurysm condition (size, shape, location, and number), preoperative Hunt-Hess grade, Fisher grade, surgery timing, and surgical complications. The patients were followed up to 6 months after surgery. The patients were divided into poor prognosis group and good prognosis group using the Glasgow Outcome Scale. Univariate and multivariate logistic analyses were performed to assess the risk factors for poor prognosis of intracranial aneurysm after interventional surgery. Results Six months after surgery, 224 cases (73.7%) had good prognosis and 80 cases (26.3%) had poor prognosis. The univariate analysis showed that there were significant differences between the poor prognosis group and good prognosis group in surgery timing, preoperative Hunt-Hess grade, Fisher grade, AR value, and incidence of complications (P<0.05), but there were no significant differences between the two groups in sex, age, incidence of concomitant hypertension and diabetes mellitus, and number, location, and diameter of aneurysms (P>0.05). The multivariate logistic regression analysis showed that surgery timing, preoperative Hunt-Hess grade, Fisher grade, AR value, and incidence of complications were influencing factors for the prognosis after interventional surgery (odds ratios=1.301, 1.328, 1.868, 1.910, and 2.083, respectively, P<0.05). Conclusions Surgery timing, preoperative Hunt-Hess grade, Fisher grade, AR value, and incidence of concomitant complications are influencing factors for the prognosis of intracranial aneurysm after interventional surgery. Operation at the earliest possible time and proactive prevention and treatment of complications are effective measures to improve the prognosis and quality of life in patients with surgical indications for aneurysm.