Objective To investigate the clinical features of dysembryoplastic neuroepithelial tumors in the temporal lobe and the extra-temporal lobe, as well as the influencing factors for prognosis.Methods A retrospective analysis was performed for the clinical data of 33 patients who were diagnosed with dysembryoplastic neuroepithelial tumors in our hospital from January 2010 to January 2019, and according to the location of tumors, they were divided into temporal lobe group and extra-temporal lobe group. The two groups were compared in terms of general data, imaging features, pathological features, and prognosis.Results Among these patients,5 (15.15%) still experienced seizures after surgery, and all of them were in the temporal lobe group. The statistical analysis showed that the patients with poor control of epilepsy after surgery tended to have a younger age of onset and a longer course of disease (P<0.05). The extra-temporal lobe group had significantly better prognosis than the temporal lobe group (P=0.018).Conclusions Location of lesion, age of onset, and duration of disease are closely associated with the prognosis of dysembryoplastic neuroepithelial tumors.