Objective To investigate the strategies and clinical effect of microsurgical resection of subdural extramedullary tumors via hemilaminectomy.Methods A retrospective analysis was performed for the clinical data of 45 patients with subdural extramedullary tumors who underwent microsurgical treatment via hemilaminectomy in our hospital from January 2014 to December 2018.Results All patients underwent microsurgical resection of subdural extramedullary tumors via hemilaminectomy and had a significant improvement in nerve dysfunction, and no serious complications were observed. The patients were followed up for 6 months to 5 years and achieved good recovery, and no recurrence was observed.Conclusions Microsurgical resection of subdural extramedullary tumors via hemilaminectomy has a marked clinical effect, with the advantages of minimal invasion, good spinal stability, and few complications.