Abstract:Objective To investigate the effect of induced hypertension on cerebral blood flow (CBF) in patients with aneurysmal subarachnoid hemorrhage.Methods We enrolled patients diagnosed with aneurysmal subarachnoid hemorrhage in our hospital from January 2015 to December 2018, and randomly divided them into induction group and control group to receive induced hypertension and non-induction treatment, respectively. After 24 to 36 hours, CBF and arterial blood pressure were assessed in both groups.Results A total of 24 patients were included in the study. Clinical data showed no significant differences between the control and induction groups. From time point CTP1 to CTP2, mean arterial blood pressure increased by 12 mmHg (95% confidence interval, 8.7 to 14.8 mmHg) in the induction group, which was higher than that in the control group. All the patients in the induction group tolerated the induced increase in blood pressure at the time of CTP2. The overall CBF change in the induction group was 0.1 (-31 to 43) ml/100 g/min, while that in the control group was -8.3 (-41 to 30) ml/100 g/min, showing no significant difference (P=0.24).Conclusions Induced hypertension has no significant effect on CBF in patients with aneurysmal subarachnoid hemorrhage.