脑灌注压对动脉瘤性蛛网膜下腔出血后迟发性脑缺血的预测价值
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Value of cerebral perfusion pressure in predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
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    目的 探讨脑灌注压(CPP)对动脉瘤性蛛网膜下腔出血(aSAH)后迟发性脑缺血(DCI)发生的预测价值。方法 纳入2016年1月至12月在我院就诊并进行CPP检测的50例aSAH患者,其中19例发生DCI。统计所有患者低于各CPP阈值的时间总比例,通过ROC曲线及二元logisctic回归分析比较CPP与DCI的相关性。结果 CPP低于50 mmHg、55 mmHg、60 mmHg、65 mmHg的时间比例对DCI的预测阈值分别为0.28%(AUC=0.778)、3.0%(AUC=0.756)、10.8%(AUC=0.749)、16.1%(AUC=0.718),经二元logistic回归分析显示均与DCI的发生相关(P<0.05)。而CPP低于70 mmHg、75 mmHg、80 mmHg的时间比例对DCI的预测阈值分别为24.8%(AUC=0.697)、49.6%(AUC=0.686)、55.9%(AUC=0.672),经二元logistic回归分析显示均与DCI无相关性(P>0.05)。结论 aSAH患者发生DCI的风险与CPP降低有关,而维持CPP在70 mmHg以上可能有助于预防DCI发生。

    Abstract:

    Objective To investigate the value of cerebral perfusion pressure (CPP) in predicting delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH).Methods A total of 50 patients with aSAH who attended our hospital and underwent CPP test from January to December, 2016, were enrolled, among whom 19 patients developed DCI. The total proportion of time below each CPP threshold was calculated for all patients and the receiver operating characteristic (ROC) curve and the binary logistic regression analysis were used to investigate the correlation between CPP and DCI.Results The thresholds for the proportion of time with a CPP of below 50 mmHg, 55 mmHg, 60 mmHg, and 65 mmHg in predicting DCI were 0.28% (area under the ROC curve[AUC]=0.778), 3.0% (AUC=0.756), 10.8% (AUC=0.749), and 16.1% (AUC=0.718), respectively, and the binary logistic regression analysis showed that these thresholds were associated with DCI (P<0.05). The thresholds for the proportion of time with a CPP of below 70 mmHg, 75 mmHg, and 80 mmHg were 24.8% (AUC=0.697), 49.6% (AUC=0.686), and 55.9% (AUC=0.672), respectively, and the binary logistic regression analysis showed that these thresholds were not associated with DCI (P>0.05).Conclusions The risk of DCI in patients with aSAH is associated with the reduction in CPP, and CPP maintained above 70 mmHg may help to prevent DCI.

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张彬456.脑灌注压对动脉瘤性蛛网膜下腔出血后迟发性脑缺血的预测价值[J].国际神经病学神经外科学杂志,2019,46(6):618-621111ZHANG Bin222. Value of cerebral perfusion pressure in predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage[J]. Journal of International Neurology and Neurosurgery,2019,46(6):618-621

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  • 收稿日期:2019-02-05
  • 最后修改日期:2019-10-30
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  • 在线发布日期: 2019-12-28
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