Objective To investigate the relationship between the C766T polymorphism in the low-density lipoprotein receptor-related protein 1 (LRP-1) gene and the risk of onset of Alzheimer's disease (AD) in China.Methods We searched Chinese Journal Full-Text Database, Medline, Cochrane Library, and China Biology Medicine disc for case-control studies about the relationship between the LRP-1 polymorphisms and Alzheimer's disease in Chinese population from January 1997 to June 2019, using keywords such as "LRP-1", "low-density lipoprotein receptor-related protein 1 gene", and "Alzheimer's disease". A meta-analysis was performed for the included studies.Results Sixteen eligible case-control studies were included. According to comprehensive data analysis, there was a significant association of AD onset with CC genotype and C allele in Chinese population (P<0.05); Han Chinese population yielded the same result. CC genotype carriers had a 1.477-fold and 1.711-fold risk of developing AD relative to CT/TT genotype carriers in Chinese and Han Chinese populations, respectively. C allele carriers had a 1.669-fold and 2.005-fold risk of developing AD relative to T allele carriers in Chinese and Han Chinese populations, respectively.Conclusions The C766T polymorphism in the LRP-1 gene is associated with the risk of onset of AD in Chinese population, especially Han Chinese population, and CC genotype or C allele carriers have a higher risk.