动脉瘤性蛛网膜下腔出血后低血钾对短期预后的影响分析
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王建村(1987-),男,副教授,硕士。主要从事脑血管病、脑胶质瘤及神经重症的临床试验研究。E-mail:WC_Jiancun@yeah.net。

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An analysis of the effect of hypokalemia after aneurysmal subarachnoid hemorrhage on short-term prognosis
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    目的 研究患者入院时血钾水平与动脉瘤性蛛网膜下腔出血短期预后的关系。方法 回顾性收集张家界市人民医院神经外科于2014年1月-2018年6月诊治的动脉瘤性蛛网膜下腔出血患者的临床资料,对符合纳入标准患者入院时的血钾水平、一般情况、Hunt-hess分级、白细胞计数、PCO2、住院时间等进行有序线性回归分析,探讨血钾水平对患者短期预后的影响并阐述其可能的机制。结果 有序多因素分析结果显示:低血钾(0~3.5mmol/L)与短期预后不良有关(P<0.05),其中0~2.9mmol/L、2.9~3.1mmol/L、3.5~5.5mmol/L(P均<0.001),趋势P值<0.05;其他危险因素包括Hunt-hess分级为Ⅰ级、Ⅱ级、Ⅲ级,动脉瘤位于前交通动脉与后交通动脉,白细胞计数正常(P<0.05);箱线图显示:随mRS14评分增高,血钾水平呈下降趋势,低血钾组mRS14评分的分布区间偏高。结论 血钾水平越低,短期预后不良可能性越大,导致住院时间延长。其他可能影响因素有Hunt-hess分级、动脉瘤部位、白细胞计数。

    Abstract:

    Objective To investigate the association between serum potassium level on admission and short-term prognosis in patients with aneurysmal subarachnoid hemorrhage.Methods The clinical data of patients with aneurysmal subarachnoid hemorrhage who were diagnosed and treated in the Department of Neurosurgery of Zhangjiajie People's Hospital between January 2014 and June 2018 were retrospectively collected. An ordered linear regression analysis was performed on the serum potassium level on admission, general status, Hunt-Hess grade, leukocyte count, PCO2, and length of hospital stay of the patients meeting the inclusion criteria to explore the effect of serum potassium level on the short-term prognosis of patients and its possible mechanism.Results The ordered multivariate analysis showed that hypokalemia (0-3.5 mmol/L) was associated with poor short-term prognosis (P<0.05), with P<0.05 for the trend at a serum potassium level of 0-2.9 mmol/L, 2.9-3.1 mmol/L, and 3.5-5.5 mmol/L (all P<0.001). Other risk factors included Hunt-Hess grades I, Ⅱ, and Ⅲ, aneurysms located in the anterior communicating artery and the posterior communicating artery, and normal leukocyte count (P<0.05). The boxplot revealed that the serum potassium level showed a downward trend with increasing mRS14 score and the distribution interval of mRS14 score in the hypokalemia group was higher.Conclusions The lower the serum potassium level, the greater the likelihood of poor short-term prognosis, which leads to a longer length of hospital stay. Other possible factors are Hunt-Hess grade, aneurysm location, and leukocyte count.

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李雪峰, 胡观成, 李飞扬, 梅苑, 张世阳, 王建村456.动脉瘤性蛛网膜下腔出血后低血钾对短期预后的影响分析[J].国际神经病学神经外科学杂志,2019,46(4):416-421111LI Xue-Feng, HU Guan-Cheng, LI Fei-Yang, MEI Yuan, ZHANG Shi-Yang, WANG Jian-Cun222. An analysis of the effect of hypokalemia after aneurysmal subarachnoid hemorrhage on short-term prognosis[J]. Journal of International Neurology and Neurosurgery,2019,46(4):416-421

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  • 收稿日期:2019-04-25
  • 最后修改日期:2019-07-22
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  • 在线发布日期: 2019-08-28
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