Objective To investigate the diagnosis and treatment regimens for traumatic brain injury with cerebrospinal fluid rhinorrhea, influencing factors for the healing of leak port, and the timing of surgical intervention. Methods A retrospective analysis was performed for the clinical data of 90 patients with traumatic brain injury and cerebrospinal fluid rhinorrhea who were treated in our hospital from June 2014 to June 2018. A univariate analysis (χ²) was used to analyze intracranial pressure, multiple fractures of the skull base, and encephalocele affected the healing of the leak port of cerebrospinal fluid rhinorrhea, and the logistic regression model was used to analyze intracranial pressure, multiple fractures of the skull base, and encephalocele were risk factors for poor healing of the leak port. The timing of surgical intervention was also analyzed. Results Intracranial pressure, multiple fractures of the skull base, and encephalocele affected the healing of the leak port of cerebrospinal fluid rhinorrhea and were significantly associated with the healing of cerebrospinal fluid rhinorrhea (P<0.05). Conclusions Surgical intervention should be performed for cerebrospinal fluid rhinorrhea patients with multiple fractures of the skull base, increased intracranial pressure, and encephalocele as early as possible, in order to promote the healing of the leak port and reduce the incidence rate of intracranial infection.