Objective To investigate the clinical effect and safety of stent-assisted coil embolization in the treatment of intracranial aneurysms.Methods A retrospective analysis was performed for the clinical data, surgical approach, complications, and prognosis of 44 patients with intracranial aneurysms who were treated with stent-assisted coil embolization in our department. The degree of immediate aneurysm embolization was evaluated according to the Raymond classification, and the modified Rankin scale (mRS) was used to evaluate clinical outcome at 6 months after surgery. Results There were 51 aneurysms in total in 44 patients. There were 28 ruptured aneurysms (54.90%) and 23 unruptured aneurysms (45.1%), and all of them were wide-necked aneurysms. The stents used in surgery included LVIS, LVIS JR., Enterprise, and LEO stents. The stent was completely released in all patients. The rate of grade I embolization was 74.5%. Of all patients, 7 (15.90%) experienced thrombosis in stent during surgery and 4 (9.09%) experienced bleeding complications. Three patients died, resulting in a mortality rate of 6.82%. At 6 months after surgery, 81.81% of the patients had a good clinical outcome (with an mRS score of 0-2).Conclusions Stent-assisted coil embolization is safe and effective in the treatment of complex aneurysms. Modification of intraoperative procedure and individualized anticoagulant therapy for patients are the main measures for reducing complications.