糖尿病性非酮症偏侧舞蹈症临床分析
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刘亚玲(1963-),女,主任医师,博士生导师、硕士生导师,主要从事神经系统变性疾病及周围神经病的研究。E-mail:lyldoctor@163.com。

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Clinical features of nonketotic diabetic hemichorea: An analysis of 7 cases
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    目的 分析糖尿病性非酮症偏侧舞蹈症的临床特性、血清学检查、影像学检查、发病机制及治疗,以指导临床诊断,提高对该病的认识。方法 回顾性分析我院收集的糖尿病性非酮症偏侧舞蹈症7例患者的临床资料。结果 7例患者,男性3例,女性4例,年龄53~87岁,平均72.1±11.7岁。6例患者既往确诊为2型糖尿病,病史1月~20年,1例既往无糖尿病病史。发病时随机血糖波动于7~27 mmol/L,5例发病时随机血糖显著升高,2例发病时随机血糖偏高。6例患者糖化血红蛋白均显著升高,1例未查。临床症状表现主要为单侧或双侧肢体或面部不自主运动。7例患者中,3例头颅CT高密度影CT,4例阴性。2例MRI-T1W1高信号,3例未查,2例阴性。所有患者未复发类似症状,例4患者死于肺癌。结论 出现不自主的偏身舞蹈动作的患者,既往血糖控制不佳或入院后查出高血糖,无论头颅CT及MRI有无典型影像学表现,控制血糖后不自主运动消失,均应考虑本病。积极控制血糖,可消除或减少舞蹈症状。

    Abstract:

    Objective To investigate the clinical features, serological examination, imaging examinations, pathogenesis, and treatment of nonketotic diabetic hemichorea, and to guide clinical diagnosis and improve the awareness of the disease.Methods A retrospective analysis was performed for the clinical data of 7 patients with nonketotic diabetic hemichorea who were admitted to our hospital.Results Among these 7 patients, there were 3 male and 4 female patients aged 53-87 years, with a mean age of 72.1±11.7 years. Of all patients, 6 were diagnosed with type 2 diabetes with a medical history of 1 month to 20 years, and one did not have a medical history of diabetes. At the time of disease onset, blood glucose fluctuated between 7 and 27 mmol/L; of all patients, 5 had a significant increase in random blood glucose at the time of onset, and 2 had relatively high blood glucose. Of all patients, 6 had a significant increase in glycosylated hemoglobin, and one did not take this examination. Clinical symptoms included involuntary movements of the limbs or the face at one or both sides. CT examination showed high density in 3 patients and yielded negative results in the other 4 patients. MRI showed that of all patients, 2 had hyperintensity on MRI-T1W1 and 2 had negative results, and MRI was not performed for the other 3 patients. No patients experienced recurrence of similar symptoms, and case 4 died of lung cancer.Conclusions This disease should be considered in patients with involuntary hemichorea who have poor blood glucose control in the past or are found to have diabetes after admission and whose involuntary movements disappear after blood glucose control, no matter whether typical imaging findings are found on head CT and MRI. Active blood glucose control may help to reduce or eliminate the symptoms of hemichorea.

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聂祥玉, 张婷, 周晓萌, 齐伟静, 刘亚玲456.糖尿病性非酮症偏侧舞蹈症临床分析[J].国际神经病学神经外科学杂志,2018,45(6):565-568111NIE Xiang-Yu, ZHANG Ting, ZHOU Xiao-Meng, Qi Wei-Jing, LIU Ya-Ling222. Clinical features of nonketotic diabetic hemichorea: An analysis of 7 cases[J]. Journal of International Neurology and Neurosurgery,2018,45(6):565-568

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  • 收稿日期:2018-04-25
  • 最后修改日期:2018-11-26
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  • 在线发布日期: 2018-12-28
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