Abstract:Objective To investigate the clinical features, serological examination, imaging examinations, pathogenesis, and treatment of nonketotic diabetic hemichorea, and to guide clinical diagnosis and improve the awareness of the disease.Methods A retrospective analysis was performed for the clinical data of 7 patients with nonketotic diabetic hemichorea who were admitted to our hospital.Results Among these 7 patients, there were 3 male and 4 female patients aged 53-87 years, with a mean age of 72.1±11.7 years. Of all patients, 6 were diagnosed with type 2 diabetes with a medical history of 1 month to 20 years, and one did not have a medical history of diabetes. At the time of disease onset, blood glucose fluctuated between 7 and 27 mmol/L; of all patients, 5 had a significant increase in random blood glucose at the time of onset, and 2 had relatively high blood glucose. Of all patients, 6 had a significant increase in glycosylated hemoglobin, and one did not take this examination. Clinical symptoms included involuntary movements of the limbs or the face at one or both sides. CT examination showed high density in 3 patients and yielded negative results in the other 4 patients. MRI showed that of all patients, 2 had hyperintensity on MRI-T1W1 and 2 had negative results, and MRI was not performed for the other 3 patients. No patients experienced recurrence of similar symptoms, and case 4 died of lung cancer.Conclusions This disease should be considered in patients with involuntary hemichorea who have poor blood glucose control in the past or are found to have diabetes after admission and whose involuntary movements disappear after blood glucose control, no matter whether typical imaging findings are found on head CT and MRI. Active blood glucose control may help to reduce or eliminate the symptoms of hemichorea.