Objective To investigate the clinical effect of haloperidol in the treatment of Tourette syndrome (TS) with electroencephalographic (EEG) abnormalities in children.Methods A total of 54 children who met the diagnostic criteria in Diagnostic and Statistical Manual of Mental Disorders-V-Text Revision were enrolled, and according to EEG findings, they were divided into abnormal EEG group and normal EEG group. Both groups were treated with haloperidol, and the Yale Global Tic Severity Scale was used to evaluate outcome before treatment and after 4 and 16 weeks of treatment.Results There were significant changes in the total scores of motor tic and vocal tic in both groups after 16 weeks of treatment (F=144.604 and 202.08, both P<0.05). Before treatment, there were no significant differences in the total scores of motor tic and vocal tic between the two groups (P>0.05); after 4 weeks of treatment, the abnormal EEG group had significantly higher total scores of motor tic and vocal tic than the normal EEG group (P<0.05); after 16 weeks of treatment, there were no significant differences in the total scores of motor tic and vocal tic between the two groups (P>0.05).Conclusions Haloperidol has a good clinical effect in the treatment of TS with abnormal EEG in children. The children with TS and abnormal EEG have a poorer short-term response than those with TS and normal EEG, while there is no significant difference in long-term response between these two groups.