Objective To assess the predictive value of laboratory parameters for the development of shunt-dependent hydrocephalus (SDHC) after aneurysmal subarachnoid hemorrhage (aSAH).Methods A total of 150 patients with aSAH who underwent clipping in our hospital from January 2014 to December 2017 were included in the study. Patients were divided into SDHC group (n=40) and non-SDHC group (n=110) according to the presence or absence of SDHC at 28 days after the onset of aSAH. The clinical data of patients were compared between the two groups. The receiver operating characteristic curve was plotted and laboratory parameters were assessed for their ability to predict SDHC after aSAH. Univariate and multivariate unconditional logistic regression analyses were performed to determine the risk factors for SDHC in patients with aSAH.Results Age, proportion of intraventricular hemorrhage, proportion of preoperative Hunt-Hess grade ≥ Ⅲ aSAH, preoperative fasting blood glucose, 3-day postoperative blood sodium and potassium levels, and 3-day postoperative fasting blood glucose were significantly different between the SDHC group and non-SDHC group (χ²=2.49, 11.15, 22.39, 5.96, 2.45, -2.69, and 5.47, respectively, all P<0.05). Univariate and multivariate logistic regression analyses showed that age ≥ 60 years, intraventricular hemorrhage, preoperative Hunt-Hess grade ≥ Ⅲ aSAH, preoperative blood potassium <3.48 mmol/L, preoperative fasting blood glucose ≥ 160.25 mg/dL, 3-day postoperative blood sodium ≥ 145.54 mg/L, 3-day postoperative blood potassium <3.02 mmol/L, and 3-day postoperative fasting blood glucose ≥ 167.55 mg/dL were risk factors for the development of SDHC after aSAH (all P<0.05).Conclusions Blood sodium and potassium levels and fasting blood glucose before and 3 days after clipping are closely associated with the development of SDHC in patients with aSAH.