Abstract:Objective To establish a rat model of severe traumatic craniocerebral injury, and to investigate the influence of three methods for the administration of 7.5% hypertonic saline (HS) on intracranial pressure (ICP) and mean blood pressure (MBP) in rats with severe traumatic craniocerebral injury.Methods A total of 50 healthy male Sprague-Dawley rats were randomly divided into group A, group B, group C, normal saline group, and blank control group, with 10 rats in each group. After modeling, group A was administered by rapid infusion, group B was administered by slow infusion, and group C was administered by rapid infusion followed by slow infusion, and the three groups were compared in terms of the changes in ICP and MBP at 1-6 hours after administration.Results Groups A, B, and C had a significant reduction in ICP after the administration of 7.5% HS, and there were no significant differences between groups A, B, and C in the lowest value of ICP, drug onset time, and time for ICP to decrease to the lowest level (P<0.001). There were also no significant differences between these three groups in the reduction in ICP and MBP before and after administration (P>0.05). The normal saline group showed no significant change in ICP after administration.Conclusions All three methods for the administration of 7.5% HS can reduce ICP, and compared with the other two methods, rapid infusion has a shorter onset time, a longer maintenance time, and a significantly greater effect in reducing ICP.