7.5%高渗盐水的不同给药方式对大鼠重型颅脑损伤后颅内压及血压的影响
作者:
作者单位:

作者简介:

许红梅(1974-)女,博士,教授,主要从事脑水肿机制研究及医院感染控制管理。E-mail:hmx58@163.com。

通信作者:

基金项目:


Influence of different methods for the administration of 7.5% hypertonic saline on intracranial pressure and blood pressure in rats with severe traumatic craniocerebral injury
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 音频文件
  • |
  • 视频文件
    摘要:

    目的 建立大鼠重型颅脑损伤模型,比较7.5%高渗盐水(HS)三种不同给药方式对重型颅脑损伤大鼠颅内压(ICP)及血压(MBP)的影响。方法 将50只健康雄性SD大鼠随机分为A组、B组、C组、生理盐水组、空白对照组,每组10只。造模后A组采用快速输注方式、B组采用缓慢输注方式、C组采用先快速后缓慢输注的方式,比较给药前及给药后1-6h内ICP及MAP的变化。结果 ① 7.5% HS三种给药方式ICP均会下降②A、B、C三组在ICP最低值、药物起效时间、ICP降至最低用时方面均有统计学差异(P<0.001).③三组ICP降幅及用药前后MBP无统计学差异(P>0.05)④生理盐水组输注前后颅内压无明显变化。结论 ①7.5% HS不同给药方式均会降低颅内高压②快速输注组起效时间更快,维持时间最长,降颅内压效果明显。

    Abstract:

    Objective To establish a rat model of severe traumatic craniocerebral injury, and to investigate the influence of three methods for the administration of 7.5% hypertonic saline (HS) on intracranial pressure (ICP) and mean blood pressure (MBP) in rats with severe traumatic craniocerebral injury.Methods A total of 50 healthy male Sprague-Dawley rats were randomly divided into group A, group B, group C, normal saline group, and blank control group, with 10 rats in each group. After modeling, group A was administered by rapid infusion, group B was administered by slow infusion, and group C was administered by rapid infusion followed by slow infusion, and the three groups were compared in terms of the changes in ICP and MBP at 1-6 hours after administration.Results Groups A, B, and C had a significant reduction in ICP after the administration of 7.5% HS, and there were no significant differences between groups A, B, and C in the lowest value of ICP, drug onset time, and time for ICP to decrease to the lowest level (P<0.001). There were also no significant differences between these three groups in the reduction in ICP and MBP before and after administration (P>0.05). The normal saline group showed no significant change in ICP after administration.Conclusions All three methods for the administration of 7.5% HS can reduce ICP, and compared with the other two methods, rapid infusion has a shorter onset time, a longer maintenance time, and a significantly greater effect in reducing ICP.

    参考文献
    相似文献
    引证文献
引用本文

蒋真真, 许红梅, 王梅林, 李泽福, 韩雪馨456.7.5%高渗盐水的不同给药方式对大鼠重型颅脑损伤后颅内压及血压的影响[J].国际神经病学神经外科学杂志,2018,45(3):247-250111JIANG Zhenzhen, XU Hongmei, WANG Meilin, LI Zefu, HAN Xuexin222. Influence of different methods for the administration of 7.5% hypertonic saline on intracranial pressure and blood pressure in rats with severe traumatic craniocerebral injury[J]. Journal of International Neurology and Neurosurgery,2018,45(3):247-250

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:2018-03-17
  • 最后修改日期:2018-05-14
  • 录用日期:
  • 在线发布日期: 2018-06-28
关闭
关闭