Objective To investigate the expression of Linc00152 in glioma and its association with prognosis.Methods The expression of Linc00152 in glioma cell line and glioma tissue was measured, and its association with clinicopathological features and prognosis was analyzed to investigate the function of Linc00152 in glioma.Results Compared with the adjacent brain tissue (73 samples), the glioma tissue (73 samples) had significantly up-regulated expression of Linc00152 (P<0.001). High expression of Linc00152 was significantly associated with advanced clinical classification of glioma (P<0.05). The Kaplan-Meier analysis showed that patients with low expression of Linc00152 had significantly longer overall survival than those with high expression of Linc00152 (P<0.001). The Cox regression analysis showed that expression of Linc00152 and clinicopathological grade were independent risk factors for the prognosis of glioma patients (P<0.05).Conclusions The expression of Linc00152 is significantly up-regulated in glioma tissue and cell lines, and high expression of Linc00152 suggests poor prognosis of glioma patients. Therefore, Linc00152 can be used as a candidate molecular maker for the prognosis of glioma and a potential molecular target for treatment.