Objective To investigate the individualized treatment of multiple intracranial aneurysms (MIAs) and the prognostic factors for MIAs.Methods A retrospective analysis was performed on the complete clinical data of 106 patients with MIAs. Univariate analysis and multivariate logistic regression analysis were used to analyze the effects of different preoperative factors and treatment regimens on treatment outcomes of the patients with MIAs.Results Of the 106 patients, 85 had a higher Glasgow Outcome Scale (GOS) score (4-5), indicating good prognosis, and 21 had a lower GOS score (1-3), indicating poor prognosis. GOS scores for different treatment groups:45 of 58 patients undergoing surgery had a good prognosis (GOS 4-5); 37 of 44 patients receiving interventional embolization had a good prognosis (GOS 4-5); 3 of 4 patients undergoing surgery combined with interventional embolization had a good prognosis (GOS 4-5). Univariate analysis showed that age, location, and preoperative Fisher grade and Hunt-Hess grade of MIAs were associated with prognosis (P<0.05). Multivariate logistic regression analysis showed that age, location, and Fisher grade of MIAs were associated with prognosis (P<0.05).Conclusions Age, location, and preoperative Fisher grade and Hunt-Hess grade are key factors affecting the treatment outcomes of patients with MIAs. According to the actual condition of patients, choosing individualized treatment regimen (such as craniotomy, interventional embolization, and craniotomy combined with interventional embolization) is the key to improving the prognosis of patients with MIAs.