Objective To explore the clinical factors influencing the short-term and long-term disease control rate in patients with intractable temporal lobe epilepsy after surgery.Methods A total of 196 patients with intractable temporal lobe epilepsy who were surgically treated were retrospectively analyzed. The disease control after surgery, as well as its relationship with clinical factors, was evaluated.Results Within 2 years after surgery, there were 142 cases of OC1 (72.4%), 10 cases of OC2 (5.1%), 25 cases of OC3 (12.8%), 14 cases of OC4 (7.1%), 5 cases of OC5 (2.6%), and 0 case of OC6 (0.0%). The excellent and good rate was 77.6%. At 3-6 years after surgery, the mean control time was 60.287±14.6181 months. Temporal lobe epilepsy classification (hazard ratio[HR]=1.763, 95% confidence interval[CI]:1.510-2.060), the course of disease[HR=1.083, 95%CI:1.045-1.122], and the frequency of acute postoperative seizures[HR=1.725, 95%CI:1.297-2.296] were independent risk factors for postoperative recurrence.Conclusions For patients with intractable temporal lobe epilepsy, surgery should be performed as early as possible based on the course of disease; preoperative classification of epilepsy, especially temporal lobe additional symptoms, can help predict postoperative epilepsy control rate; it is significant for increasing the postoperative long-term control rate of temporal lobe epilepsy to reduce the frequency of perioperative seizures.