Objective To investigate the efficacy and safety of intra-arterial infusion of tirofiban hydrochloride in managing acute thromboembolism occurring during stent-assisted coil embolization for ruptured intracranial aneurysms.Methods A total of 11 patients who developed acute thromboembolism during embolization for intracranial aneurysms from January 2013 to June 2017 were enrolled in this study. After thromboembolism occurred, targeted infusion of tirofiban hydrochloride (6 ml) was carried out using a microcatheter; meanwhile, tirofiban hydrochloride was given by intravenous pumping at 5 ml/h. Then, the recanalization of the vessels was assessed by angiography every 5-10 minutes until the thrombus disappeared or the vessels were recanalized. Computed tomography (CT) or magnetic resonance imaging (MRI) follow-up was performed postoperatively to observe the presence or absence of cerebral infarction or hemorrhage.Results Angiography performed during the procedure showed that all the diseased vessels of the 11 patients were recanalized, and no cerebral infarction or hemorrhage associated with the operation was detected on brain CT or MRI at 1 and 7 days and a month after the operation.Conclusions For acute thromboembolism occurring during stent-assisted coil embolization for ruptured intracranial aneurysms, intra-arterial infusion of tirofiban is a safe and effective treatment.