Objective To investigate the clinical effect and safety of interventional embolization combined with microsurgery in the hybrid operating room versus microsurgery alone in the treatment of hemorrhage from cerebral arteriovenous malformations (AVMs).Methods A retrospective analysis was performed on the clinical data of 10 patients who underwent interventional embolization combined with microsurgery in the hybrid operating room in the treatment of hemorrhage from AVMs, as well as 10 patients who underwent microsurgery alone for this disease. The two groups were compared in terms of preoperative Glasgow Coma Scale score and Spetzler and Martin grade, intraoperative blood loss, postoperative complications, and modified Rankin Scale and Glasgow Outcome Scale scores at 3 months after surgery.Results In the interventional embolization+microsurgery group, AVMs were resected completely in most cases, avoiding secondary surgery. Compared with the microsurgery group, the interventional embolization+microsurgery group had significantly less intraoperative blood loss and a significantly lower incidence of postoperative complications (both P<0.05).Conclusions For hemorrhage from AVMs, interventional embolization combined with microsurgery in the hybrid operating room is superior to microsurgery alone in terms of intraoperative blood loss, postoperative complications, and postoperative disability.