Objective To investigate the clinical effect of neuronavigation-guided multi-target hard-channel technique in the treatment of hypertensive basal ganglia hemorrhage.Methods A total of 80 patients were divided into treatment group and control group, with 40 patients in each group. For the patients in the treatment group, neuronavigation was used to determine the site, angle, and depth of puncture, and the multi-target hard-channel technique was used for minimally invasive therapy; for those in the control group, microsurgery was given via the lateral fissure-insular approach. The clinical outcome was compared between the two groups.Results There were significant differences between the two groups in hematoma clearance rate at 6 hours after surgery, mean time of operation, incidence rate of pulmonary infection at 3 days after surgery, and Glasgow Outcome Scale score at 1 month after surgery (P<0.05); however, there were no significant differences in hematoma clearance rate and rebleeding rate between the two groups at about 48 hours after surgery (P>0.05).Conclusions In the treatment of hypertensive basal ganglia hemorrhage, the neuronavigation-guided multi-target hard-channel technique has a good clinical effect and can reduce mortality rate and postoperative pulmonary infection. Therefore, it holds promise for clinical application.