Objective To investigate the association between DJ-1 gene polymorphisms and susceptibility to Parkinson's disease (PD).Methods CNKI, Wanfang Data, Web of Science, PubMed, EMBASE, and Cochrane Library were searched for articles published from January 1, 2001 to January 1, 2017. The inclusion and exclusion criteria for articles were determined, and the Newcastle-Ottawa Scale was used for quality evaluation. Related data were extracted from high-quality articles and the stata12.0 software was used for the statistical analysis.Results Twelve articles were included, with 2895 patients in case group and 2817 healthy controls. The meta-analysis showed that in patients with PD, DJ-1 gene g.168_185del deletion mutation[odds ratio (OR)=1.26, 95% confidence interval (CI) 1.06-1.50, P<0.05) and c.G293A point mutation (OR=2.74, 95%CI 1.22-6.16, P<0.05) were risk factors for PD. The subgroup analysis of the association between g.168_185del and PD showed that g.168_185del polymorphism was also a risk factor for PD in non-Chinese populations (OR=1.41, 95%CI 1.14-1.73, P<0.05), but such association was not observed in the Chinese population (OR=0.98, 95%CI 0.72-1.34, P>0.05). The case-control study of the association between c.G293A polymorphism and PD was conducted in non-Chinese populations, so a subgroup analysis was not performed.Conclusions DJ-1 gene g.168_185del deletion mutation and c.G293A point mutation are risk factors for PD, while this meta-analysis does not find the association between these polymorphisms and PD in the Chinese population.