Objective To investigate the clinical features and electroencephalographic findings of post-stroke epilepsy (PSE) in elderly patients and related risk factors, and to provide a basis for early prevention of epilepsy.Methods A total of 1485 patients with stroke who were admitted to Danzhou People's Hospital were enrolled and finally 992 patients were enrolled in the study. Their clinical features and electroencephalographic findings were analyzed. According to the presence or absence of PSE, these patients were divided into PSE group with 87 patients and non-PSE group with 905 patients. The univariate and multivariate logistic regression analyses were used to investigate the risk factors for PSE.Results The incidence rate of PSE was 8.77%, and among the patients with PSE, 55.17% had early-onset epilepsy and 44.83% had delayed epilepsy. As for the electroencephalographic findings of PSE, 26.44% of all patients had diffuse abnormalities and 48.28% had local abnormalities. The univariate and multivariate logistic regression analyses showed that hyperhomocysteinemia[odds ratio (OR)=2.063, 95% confidence interval (CI) 1.146-3.125), location of lesion (OR=6.285, 95%CI 5.168-9.047), extent of lesions (OR=4.725, 95%CI 3.684-6.835), electrolyte disturbance (OR=3.029, 95%CI 2.016-4.532), activities of daily living (OR=2.538, 95%CI 1.568-3.562), and NIH Stroke Scale score ≥ 25 (OR=3.163, 95%CI 2.085-4.726) were independent risk factors for PSE.Conclusions PSE has a high incidence rate in elderly patients with many risk factors, and the development of epilepsy should be closely monitored in patients with related risk factors.