Objective To investigate the effects of hepcidin on iron metabolism and neurological function in patients with cerebral hemorrhage.Methods A total of 69 patients with hypertensive intracerebral hemorrhage were used as observation group, and another 69 healthy subjects were used as control group. The serum hepcidin levels in the two groups were determined, the serum ferritin levels and indicators of neurological function (serum S100β protein and serum neuron-specific enolase[NSE]) in observation group were also determined, and the prognosis of patients in observation group was evaluated according to the modified Rankin Scale. The serum hepcidin and ferritin levels were compared between the two groups. The 69 patients in observation group were divided into group I (Hep <20 μg/L), group Ⅱ (Hep 20-30 μg/L), and group Ⅲ (Hep ≥ 30 μg/L), and the neurological function and prognosis of the three subgroups were compared.Results The observation group had significantly higher mean serum hepcidin and ferritin levels than the control group (P<0.05). The mean levels of serum S100β protein and NSE were highest in group Ⅲ and lowest in group I (P<0.05). The good prognosis rate was highest in group I and lowest in group Ⅲ (P<0.05).Conclusions Patients with cerebral hemorrhage have a significantly increased level of serum hepcidin, which is associated with the imbalance of iron metabolism, and the degree of elevation is consistent with the severity and poor prognosis of patients with neurological deficit.