Objective To investigate the association between polymorphism of rs4963 in the α-adducin gene and cerebral hemorrhage.Methods A total of 238 patients with cerebral hemorrhage and 240 healthy controls were collected in Gansu, China. Blood genomic DNA extraction kit was used to evaluate the polymorphism of rs4963 in the α-adducin gene, and the genotype and allele frequencies of rs4963 polymorphism were compared between the cerebral hemorrhage group and the control group.Results There were no significant differences in the genotype and allele frequencies between the cerebral hemorrhage group and the control group (P>0.05), even after the two groups were stratified by sex (P>0.05).Conclusions The polymorphism of rs4963 in the α-adducin gene is not associated with cerebral hemorrhage.