Objective To investigate the clinical features of hypothyroid myopathy, to increase the knowledge of hypothyroid myopathy in clinical diagnosis and treatment, and to reduce misdiagnosis and mistreatment.Methods A retrospective analysis was performed for the clinical features, laboratory examination, and auxiliary examination of 11 patients with hypothyroid myopathy who were admitted to our hospital within the past 10 years, and related articles were reviewed to investigate the possible pathophysiological mechanism of this disease.Results Hypothyroid myopathy had complex clinical manifestations. The patients with this disease often had abnormal results of routine blood test, muscle enzymes, and blood lipids, while there were no specific changes in electromyographic results. Thyroid hormone replacement therapy was effective in the treatment of this disease.Conclusions In the diagnosis and treatment of neurological diseases, thyroid stimulating hormone should be measured in patients with chief complaints of muscle weakness and muscle pain, in order to reduce the misdiagnosis and mistreatment of hypothyroid myopathy.