Objective To investigate the clinicopathologic features of 15 patients with refractory epilepsy induced by cerebrovascular malformation undergoing surgical operation for epilepsy.Methods A retrospective analysis was performed for the clinical and pathological data of 15 patients with cerebrovascular malformation who underwent the resection of brain lesions and epileptic lesions.Results All the 15 patients had refractory epilepsy; among them, 8 had cavernous angioma and 7 had Sturge-Weber syndrome (SWS). There were 8 male and 7 female patients, with an age of onset of 1 month to 29 years and a course of the disease of 2-24 years. The age when they underwent the surgery ranged 2-31 years. Of all patients, 2 underwent single lobe resection, 12 underwent multilobar resection, and 1 underwent functional hemispherectomy. The microscopic evaluation of brain specimens showed cavernous angioma complicated by focal cortical dysplasia (FCD) type IIIc, as well as hemangioma in pia mater, diffuse calcification in gray matter, calcification of small vessel wall in brain parenchyma, and FCD type IIIc. The patients were followed up for 0.5-8 years after surgery, and of all patients, 12 had Engel grade I, 2 had Engel grade II, 1 had Engel grade III, and 1 had Engel grade IV.Conclusions The patients with cavernous angioma have a good outcome during follow-up after surgical operation for epilepsy. In patients with SWS, the degree of intracranial lesions may be associated with genetics. The patients with SWS type I should undergo operation as soon as possible so as to achieve a good outcome during follow-up, and those with SWS type III should undergo resection of hemangioma lesions and epileptic lesions to achieve a good outcome.