Objective Reports of surgical treatment of cerebral cavernous malformations are rare. Therefore, we will discuss the clinical features and surgical outcomes of patients with multiple cerebral cavernous malformations.Methods Thirty-nine multiple cerebral cavernous malformation patients treated with surgical operation were analyzed retrospectively. The modified Rankin Scale (mRS) was used to assess the nerve functions of those patients. We used paired t-test to compare preoperative and follow-up mRS scores. Pearson's correlation analysis was applied to determine the association of age, number of lesions, and preoperative mRS scores with the patient's prognosis.Results One patient experienced partial facial paralysis following the resection of cavernous malformation in the cerebellar peduncle, while another patient experienced hemiplegia after the resection of cavernous malformation in the pontine area. After treatment, these two patients' conditions improved. During the follow-up period of 29.5 months on average, no patients bled again. Sixteen patients (41%) had significant improvement in nerve functions, 23 patients (59%) showed no change in nerve functions, and no patient became worse during the follow-up. Statistical analysis indicated a significant difference between the preoperative and follow-up mRS scores (P=0.01). Sex, age, the time from initial symptoms to operation, the number of lesions, the number of times of bleeding, and the time of follow-up are not associated with the prognosis. The lesion location during surgery (P=0.02) and preoperative mRS score (P=0.01) were associated with the patient's prognosis.Conclusions Surgical resection of the lesions can achieve good results in most patients with multiple cerebral cavernous malformations. The lesion location during surgery and the preoperative mRS score are relevant factors that will affect the prognosis of patients.